東京医科歯科大学の救命救急センターは内科外科などの専門領域を問わず全ての重症度の救急患者の初期診療から集中治療までを担っています。診療のあらゆる場面を医学教育とリンクさせ、総合診療と救急医療の教育に重点を置いています。更に、外傷診療、心肺蘇生、災害医療などの豊富なシミュレーション教育を導入し、多角的な教育を実現しています。
基礎研究は、「過大侵襲後の臓器不全の発症機序の解明」をテーマとして、現在、急性炎症におけるカルシウム非依存性ホスホリパーゼA2や迷走神経刺激、ω-3系脂肪酸の役割について、in vivoおよびin vitroの両面から研究を行っています。
臨床研究では、臨床疫学と正しい統計手法に基づき、救急医療のエビデンスを前進させることを目的とし、初期診療に資する観察研究、コホート研究、介入研究を行なっています。
Junichi Inoue，Atsushi Shiraishi，Ayako Yoshiyuki，Koichi Haruta，Hiroki Matsui，Yasuhiro Otomo：Resuscitative endovascular balloon occlusion of the aorta might be dangerous in patients with severe torso trauma: a propensity score analysis. J Trauma Acute Care Surg. 80(4):559-566, 2016.
Endo A, Shiraishi A, Matsui H, Hondo K, Otomo Y. Assessment of Progress in Early Trauma Care in Japan over the Past Decade: Achievements and Areas for Future Improvement. J Am Coll Surg. 224(2):191-198.e5, 2017.
Endo A, Shiraishi A, Otomo Y, Kushimoto S, Saitoh D, Hayakawa M, Ogura H, Murata K, Hagiwara A, Sasaki J, Matsuoka T, Uejima T, Morimura N, Ishikura H, Takeda M, Kaneko N, Kato H, Kudo D, Kanemura T, Shibusawa T, Hagiwara Y, Furugori S, Nakamura Y, Maekawa K, Mayama G, Yaguchi A, Kim S, Takasu O, Nishiyama K.
Development of Novel Criteria of the "Lethal Triad" as an Indicator of Decision Making in Current Trauma Care: A Retrospective Multicenter Observational Study in Japan. Crit Care Med. 44(9):e797-803, 2016.
Kojima Mitsuaki，Aiboshi Junichi，Shibata Masahiro，Kobayashi Tetsuyuki，Otomo Yasuhiro：Novel role of group VIB Ca2+-independent phospholipase A2gamma in leukocyte-endothelial cell interactions：An intravital microscopic study in rat mesentery. J Trauma Acute Care Surg 79(5)：782-789，2015.
Mikami Saori，Aiboshi Junichi，Kobayashi Tetsuyuki，Kojima Mitsuaki，Morishita Koji，Otomo Yasuhiro：Discrete roles of intracellular phospholipases A2 in human neutrophil cytotoxicity. J Trauma Acute Care Surg 79(2)：238-246，2015.
Ushizawa Hiroto，Yahata Yuichiro，Endo Takeo，Iwashima Tomoko，Misawa Michiyo，Sonobe Makoto，Yamagishi Takuya，Kamiya Hajime，Nakashima Kazutoshi，Matsui Tamano，Matsui Mari，Suzuki Satowa，Shibayama Keigo，Doi Mikio，Irie Fujiko，Yamato Shinichi，Otomo Yasuhiro，Oishi Kazunori：An Epidemiological Investigation of a Nosocomial Outbreak of Multidrug-resistant Acinetobacter baumannii in a Critical Care Center in Japan, 2011-2012. Jpn J Infect 2015.
Yamanouchi Satoshi，Sasaki Hiroyuki，Tsuruwa Miho，Ueki Yuzuru，Kohayagawa Yoshitaka，Kondo Hisayoshi，Otomo Yasuhiro，Koido Yuichi，Kushimoto Shigeki：Survey of preventable disaster death at medical institutions in areas affected by the Great East Japan Earthquake：a retrospective preliminary investigation of medical institutions in Miyagi Prefecture. Prehosp Disaster Med 30(2)：145-151，2015.
Koji Morishita，Todd W：Costantini, Akinori Ueno, Vishal Bansal, Brian Eliceiri, Raul Coimbra. A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock．J Trauma Acute Care Surg 78(1)：52-59，2015.
Morishita Koji，Coimbra Raul，Langness Simone，Eliceiri Brian P，Costantini Todd W：The neuro-enteric axis modulates the balance of regulatory T cells and T-helper 17 cells in the mesenteric lymph node following trauma/hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 309(3)：G202-208, 2015.
